ARL6

Across TCGA patient cohorts, ARL6 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL6-associated genes across cancer lineages are FoxM1, JNK2, and p90 RSK_pT359_S363. Each is linked with ARL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL6-to-partner and partner-to-ARL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ARL6-low versus ARL6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL6→partner) and Y-score (partner→ARL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.277	+2.817	.041	.036	3	1
UCEC	JNK2 →	+0.430	+3.321	<.001	.010	3	1
UCEC	p90 RSK_pT359_S363 →	-0.221	-2.999	.037	.035	3	1
UCEC	PKC-b-II_pS660 →	-0.395	-3.000	.006	.036	3	1
UCEC	Shc_pY317 →	-0.252	-3.169	.001	.019	3	1
UCEC	Chk2_pT68 →	-0.211	-3.321	.030	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FoxM1 by ARL6 expression — UCEC

Explore this box plot interactively →