ARL4D

Across TCGA pan-cancer cohorts, ARL4D RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ARL4D data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ARL4D RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARL4D expression acts as an unfavorable survival marker, although some lineages such as UCEC and ACC show a favorable association.

HNSC, UCEC, and KIRC are the cancer types where ARL4D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.526	0.680	<.001	135	view →
UCEC	DFS	Median	All	0.809	0.531	<.001	116	view →
KIRC	DFS	Tertile	II,III,IV	0.695	0.893	.001	69	view →
LUAD	OS	Quartile	III,IV	0.172	0.419	.001	55	view →
SKCM	OS	Tertile	All	0.741	0.838	.006	40	view →
PAAD	OS	Median	All	0.524	0.750	.002	34	view →
UCS	OS	Median	III,IV	0.371	0.741	.004	26	view →
BLCA	OS	Quartile	All	0.612	0.798	.005	25	view →
ACC	DFS	Tertile	IV	0.619	0.154	.001	20	view →
SARC	OS	Tertile	All	0.822	0.571	<.001	18	view →
LAML	DFS	Median	All	0.487	0.654	.016	14	view →
THYM	DFS	Tertile	II,III,IV	0.922	0.584	.011	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ARL4D–HNSC (DFS)

Open the HNSC breakdown →