Across TCGA pan-cancer cohorts, ARL4AP3 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ARL4AP3’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ARL4AP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARL4AP3 is over-expressed in tumor, although a few such as CHOL and KICH show the opposite, repressed pattern.
LUSC, CHOL, and ESCA are the cancer types where ARL4AP3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARL4AP3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.