ARL4A

Across TCGA pan-cancer cohorts, ARL4A RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ARL4A data layer compared with 5 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ARL4A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARL4A expression acts as an unfavorable survival marker, although some lineages such as KIRC and CHOL show a favorable association.

BLCA, ACC, and KIRP are the cancer types where ARL4A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	II,III,IV	0.406	0.580	.001	118	view →
ACC	DFS	Median	All	0.226	0.659	<.001	102	view →
KIRP	DFS	Quartile	III,IV	0.159	0.767	<.001	70	view →
KICH	DFS	Quartile	III,IV	0.181	1.000	.002	54	view →
KIRC	DFS	Median	All	0.883	0.705	<.001	35	view →
THCA	OS	Median	II,III,IV	0.749	0.960	.001	30	view →
LUSC	OS	Quartile	III,IV	0.261	0.533	.009	22	view →
LIHC	OS	Tertile	All	0.697	0.850	.002	16	view →
CESC	OS	Tertile	IV	0.191	0.727	.026	12	view →
CHOL	DFS	Tertile	III,IV	0.751	0.154	.024	12	view →
UVM	DFS	Median	III,IV	0.287	0.667	.023	9	view →
READ	DFS	Quartile	IV	0.309	0.823	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ARL4A–BLCA (DFS)

Open the BLCA breakdown →