ARL3

Across TCGA patient cohorts, ARL3 mutation is significantly associated with the RNA expression of many other genes, with 168 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ARL3-associated genes across cancer lineages are RNU6-844P, IGLVI-68, and VN1R6P. Each is linked with ARL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL3-to-partner and partner-to-ARL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-844P grouped by ARL3-low versus ARL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL3→partner) and Y-score (partner→ARL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-844P →	+0.491	+2.595	.007	.005	3	2
UCEC	IGLVI-68 →	+0.117	+3.630	<.001	.003	3	2
SKCM	VN1R6P →	+0.087	+5.080	<.001	.004	3	2
SKCM	GPN3P1 →	+0.082	+5.328	<.001	.003	3	2
BRCA	MIR6853 →	+0.364	+9.057	<.001	.003	3	1
BRCA	MIR6130 →	+0.333	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 168 associations by consensus.

RNU6-844P by ARL3 expression — UCEC

Explore this box plot interactively →