Across TCGA pan-cancer cohorts, ARL2BPP6 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ARL2BPP6’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ARL2BPP6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARL2BPP6 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
BLCA and THCA are the cancer types where ARL2BPP6 tumor–normal differential expression is most reproducible.