Across TCGA patient cohorts, ARL16 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ARL16-associated genes across cancer lineages are GSK-3a-b_pS21_S9, Heregulin, and Acetyl-a-Tubulin-Lys40. Each is linked with ARL16 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL16-to-partner and partner-to-ARL16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL16→partner) and Y-score (partner→ARL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GSK-3a-b_pS21_S9 →	-0.474	-2.000	.011	.031	3	1
SKCM	Heregulin →	+0.168	+3.472	.029	.002	3	1
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.518	+3.000	.035	.034	3	1
SKCM	MSH2 →	+0.304	+2.017	.002	.018	3	1
SKCM	N-Ras →	+0.139	+3.321	.023	.009	3	1
SKCM	PI3K-p110-a →	+0.157	+2.000	.022	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

ARL16 survival (RNA) · tumor vs normal (RNA) · all ARL16 data types