Across TCGA patient cohorts, ARL15 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL15-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and GAPDH. Each is linked with ARL15 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL15-to-partner and partner-to-ARL15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL15→partner) and Y-score (partner→ARL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.266	-2.459	.010	.018	3	1
UCEC	FoxM1 →	+0.295	+2.321	.005	.006	3	1
UCEC	GAPDH →	+0.519	+1.874	.019	.049	3	1
UCEC	ACC1 →	+0.313	+2.321	.037	.006	3	1
UCEC	HER2_pY1248 →	-0.222	-3.000	.044	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.221	-3.584	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

ARL15 survival (RNA) · tumor vs normal (RNA) · all ARL15 data types