ARL1

Across TCGA patient cohorts, ARL1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL1-associated genes across cancer lineages are MEK1, p62 Lck ligand, and PDK1_pS241. Each is linked with ARL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL1-to-partner and partner-to-ARL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ARL1-low versus ARL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL1→partner) and Y-score (partner→ARL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.400	+2.321	.018	.034	3	1
UCEC	p62 Lck ligand →	+0.414	+2.999	.006	.035	3	1
UCEC	PDK1_pS241 →	+0.217	+1.887	.006	.031	3	1
UCEC	Rab25 →	-0.464	-2.999	.002	.035	3	1
UCEC	Shc_pY317 →	-0.185	-2.459	.008	.019	3	1
UCEC	TIGAR →	+0.167	+2.611	.018	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MEK1 by ARL1 expression — UCEC

Explore this box plot interactively →