ARIH2

Across TCGA cell cohorts, ARIH2 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARIH2-associated genes across cancer lineages are GSG1L2, GML, and C9. Each is linked with ARIH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARIH2-to-partner and partner-to-ARIH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by ARIH2-low versus ARIH2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARIH2→partner) and Y-score (partner→ARIH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
BLOOD_Leukemia	GML →	+0.067	+2.982	<.001	.007	3	1
BLOOD_Leukemia	C9 →	+1.019	+3.775	<.001	.004	3	1
BLOOD_Leukemia	IL22 →	+0.021	+4.247	<.001	.004	3	1
BLOOD_Leukemia	IL36A →	+0.587	+3.536	.005	.008	3	1
BLOOD_Leukemia	EGFLAM →	+0.192	+3.710	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

GSG1L2 by ARIH2 expression — LARGE_INTESTINE

Explore this box plot interactively →