ARIH1

Across TCGA patient cohorts, ARIH1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARIH1-associated genes across cancer lineages are MEK1, Notch1, and p62 Lck ligand. Each is linked with ARIH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARIH1-to-partner and partner-to-ARIH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ARIH1-low versus ARIH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARIH1→partner) and Y-score (partner→ARIH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.476	+3.459	.005	.005	3	1
UCEC	Notch1 →	+0.222	+3.183	<.001	.009	3	1
UCEC	p62 Lck ligand →	+0.384	+3.331	.011	.005	3	1
UCEC	STAT3_pY705 →	-0.417	-2.321	<.001	.033	3	1
UCEC	ATM →	-0.482	-3.169	.022	.019	3	1
UCEC	4E-BP1_pT37_T46 →	-0.455	-2.986	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MEK1 by ARIH1 expression — UCEC

Explore this box plot interactively →