Across TCGA cell cohorts, ARID3C mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARID3C-associated genes across cancer lineages are Sabutoclax, KRAS (G12C) Inhibitor-12, and WYE-125132. Each is linked with ARID3C in more than 1 cancer types. Because this analysis shows association rather than direction, both ARID3C-to-partner and partner-to-ARID3C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARID3C→partner) and Y-score (partner→ARID3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Sabutoclax →	+0.501	+2.769	.017	.040	3	2
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.544	+2.646	.029	.047	3	1
LARGE_INTESTINE	WYE-125132 →	+0.613	+2.652	.015	.045	3	1
LARGE_INTESTINE	CP466722 →	+0.390	+2.652	.049	.045	1	1
LARGE_INTESTINE	Uprosertib →	+0.627	+2.646	.038	.047	1	1
LARGE_INTESTINE	CDK9_5038 →	+0.702	+2.906	.010	.033	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

ARID3C survival (RNA) · tumor vs normal (RNA) · all ARID3C data types