ARID3B

Across TCGA pan-cancer cohorts, ARID3B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ARID3B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARID3B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARID3B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where ARID3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARID3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.785	<.001	11	view →
BLCA	Male	III,IV	+1.574	<.001	7	view →
LIHC	Female	All	+0.734	<.001	7	view →
THCA	All	All	−0.350	<.001	7	view →
KIRC	All	All	+0.307	<.001	7	view →
UCEC	All	III,IV	+1.346	<.001	6	view →
STAD	All	II,III,IV	+0.800	<.001	6	view →
CHOL	Male	All	+1.443	<.001	5	view →
LUSC	Male	All	+0.411	<.001	4	view →
KICH	All	All	−0.399	<.001	4	view →
BRCA	All	All	+0.145	.018	3	view →
PRAD	All	All	+0.291	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ARID3B–HNSC

Open the HNSC breakdown →