ARID3A

Across TCGA patient cohorts, ARID3A mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARID3A-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and MEK1. Each is linked with ARID3A in more than 1 cancer types. Because this analysis shows association rather than direction, both ARID3A-to-partner and partner-to-ARID3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ARID3A-low versus ARID3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARID3A→partner) and Y-score (partner→ARID3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.176	+2.584	.043	.010	3	1
UCEC	A-Raf_pS299 →	-0.165	-2.321	<.001	.034	3	1
UCEC	MEK1 →	+0.388	+2.321	.010	.006	3	1
UCEC	Notch1 →	+0.168	+2.009	.003	.017	3	1
UCEC	p27 →	+0.187	+2.321	.038	.006	3	1
UCEC	PAI-1 →	-0.310	-3.169	.028	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eIF4E by ARID3A expression — UCEC

Explore this box plot interactively →