ARID1A

Across TCGA patient cohorts, ARID1A RNA expression is significantly associated with the protein abundance of many other proteins, with 13,173 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ARID1A-associated proteins across cancer lineages are SPEN_S727, TOP2B_S1524, and SF3B3. Each is linked with ARID1A in more than 4 cancer types. Because this analysis shows association rather than direction, both ARID1A-to-partner and partner-to-ARID1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARID1A versus SPEN_S727 in PDAC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARID1A→partner) and Y-score (partner→ARID1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SPEN_S727 →	+0.582	+0.357	.002	.002	3	5
HNSC	TOP2B_S1524 →	+0.676	+0.539	.003	.001	3	5
GBM	SF3B3 →	+0.224	+0.472	<.001	<.001	3	5
GBM	BUB3 →	+0.293	+0.539	<.001	<.001	3	5
LSCC	EIF4A3 →	+0.241	+0.512	.002	.001	3	5
GBM	GATAD2B →	+0.288	+0.571	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,173 associations by consensus.

ARID1A vs SPEN_S727 — PDAC

Explore this scatter interactively →