ARID1A

Across TCGA patient cohorts, ARID1A protein abundance is significantly associated with the RNA expression of many other genes, with 14,714 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ARID1A-associated genes across cancer lineages are RBBP4, KDF1, and SRSF10. Each is linked with ARID1A in more than 6 cancer types. Because this analysis shows association rather than direction, both ARID1A-to-partner and partner-to-ARID1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARID1A versus RBBP4 in LSCC, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARID1A→partner) and Y-score (partner→ARID1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RBBP4 →	+0.570	+0.331	<.001	<.001	3	7
LSCC	KDF1 →	+0.798	+0.294	<.001	<.001	3	6
BRCA	SRSF10 →	+0.457	+0.322	<.001	<.001	3	6
LSCC	PPP1R8 →	+0.465	+0.321	<.001	<.001	3	6
OV	GPN2 →	+0.683	+0.295	.001	.001	3	6
BRCA	GPATCH3 →	+0.447	+0.224	.001	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,714 associations by consensus.

ARID1A vs RBBP4 — LSCC

Explore this scatter interactively →