ARID1A

Across TCGA patient cohorts, ARID1A mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARID1A-associated genes across cancer lineages are C-Raf, PREX1, and Caspase-7-cleavedD198. Each is linked with ARID1A in more than 4 cancer types. Because this analysis shows association rather than direction, both ARID1A-to-partner and partner-to-ARID1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by ARID1A-low versus ARID1A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARID1A→partner) and Y-score (partner→ARID1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.104	+2.493	.020	.009	3	5
STAD	PREX1 →	+0.252	+2.415	<.001	.002	3	4
STAD	Caspase-7-cleavedD198 →	+1.000	+2.392	<.001	<.001	3	4
STAD	Cyclin-B1 →	+0.358	+1.662	.015	.010	3	4
STAD	Syk →	+0.338	+2.321	.007	.004	3	3
STAD	YAP_pS127 →	-0.280	-3.700	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

C-Raf by ARID1A expression — COAD

Explore this box plot interactively →