ARHGEF9

Across TCGA patient cohorts, ARHGEF9 protein abundance is significantly associated with the RNA expression of many other genes, with 6,069 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ARHGEF9-associated genes across cancer lineages are POLR3DP1, AKAIN1, and TUBB1. Each is linked with ARHGEF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF9-to-partner and partner-to-ARHGEF9 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF9 versus POLR3DP1 in GBM, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF9→partner) and Y-score (partner→ARHGEF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	POLR3DP1 →	+0.373	+0.370	.001	<.001	3	2
GBM	AKAIN1 →	+0.129	+0.291	<.001	<.001	3	2
CCRCC	TUBB1 →	-0.552	-0.419	<.001	.001	3	1
CCRCC	HOXA2 →	-0.701	-0.434	.003	.002	3	1
CCRCC	NEK4 →	-0.228	-0.707	.009	.007	3	1
CCRCC	FOXP2 →	+1.532	+0.447	.001	.007	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,069 associations by consensus.

ARHGEF9 vs POLR3DP1 — GBM

Explore this scatter interactively →