ARHGEF9

Across TCGA patient cohorts, ARHGEF9 mutation is significantly associated with the RNA expression of many other genes, with 5,413 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF9-associated genes across cancer lineages are MIR3912, RNA5SP364, and CBX3P8. Each is linked with ARHGEF9 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF9-to-partner and partner-to-ARHGEF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3912 grouped by ARHGEF9-low versus ARHGEF9-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF9→partner) and Y-score (partner→ARHGEF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR3912 →	+0.229	+2.826	.001	.006	3	3
HNSC	RNA5SP364 →	+0.557	+4.122	.001	.004	3	2
HNSC	CBX3P8 →	+0.052	+4.636	<.001	.006	3	2
READ	MIRLET7F1 →	+0.573	+4.533	<.001	.004	3	2
READ	NPLP1 →	+0.229	+4.421	<.001	.009	3	2
READ	MIR3619 →	+1.035	+4.361	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,413 associations by consensus.

MIR3912 by ARHGEF9 expression — CESC

Explore this box plot interactively →