ARHGEF9

Across TCGA patient cohorts, ARHGEF9 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF9-associated genes across cancer lineages are Annexin-1, STAT5a, and ATM. Each is linked with ARHGEF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF9-to-partner and partner-to-ARHGEF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by ARHGEF9-low versus ARHGEF9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF9→partner) and Y-score (partner→ARHGEF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.608	+1.947	<.001	<.001	3	2
UCEC	STAT5a →	+0.312	+1.807	.010	.024	3	2
UCEC	ATM →	-0.375	-1.700	.006	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.660	+2.502	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.074	-1.673	.016	.040	3	1
UCEC	EGFR_pY1068 →	-0.233	-1.947	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Annexin-1 by ARHGEF9 expression — UCEC

Explore this box plot interactively →