ARHGEF9

Across TCGA cell cohorts, ARHGEF9 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,820 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARHGEF9-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Positive regulation of intracellular estrogen receptor signaling pathway, and Negative regulation of maintenance of sister chromatid cohesion. Each is linked with ARHGEF9 in more than 9 cancer types. Because this analysis shows association rather than direction, both ARHGEF9-to-partner and partner-to-ARHGEF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by ARHGEF9-low versus ARHGEF9-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF9→partner) and Y-score (partner→ARHGEF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.119	+1.295	.003	.001	2	10
BLOOD_Lymphoma	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.080	+0.964	.002	.001	3	7
BLOOD_Myeloma	Negative regulation of maintenance of sister chromatid cohesion →	+0.104	+1.089	<.001	<.001	3	7
BLOOD_Myeloma	Negative regulation of maintenance of mitotic sister chromatid cohesion →	+0.104	+1.089	<.001	<.001	3	7
SKIN	Response to flavonoid →	+0.093	+0.981	<.001	<.001	3	7
LUNG_NSCLC_LUSC	Cholesterol homeostasis →	-0.054	-1.192	.004	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,820 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by ARHGEF9 expression — LUNG_SCLC

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