ARHGEF9

Across TCGA cell cohorts, ARHGEF9 mutation is significantly associated with the mutation status of many other genes, with 171 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible ARHGEF9-associated genes across cancer lineages are BMP15, RAG2, and ZNF669. Each is linked with ARHGEF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF9-to-partner and partner-to-ARHGEF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP15 grouped by ARHGEF9-low versus ARHGEF9-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF9→partner) and Y-score (partner→ARHGEF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BMP15 →	+4.502	+5.066	.007	.007	1	2
UPPER_AERODIGESTIVE_TRACT	RAG2 →	+5.392	+5.392	.004	.004	1	2
LUNG_SCLC	ZNF669 →	+5.502	+5.502	.003	.003	1	2
UPPER_AERODIGESTIVE_TRACT	HDAC11 →	+5.392	+5.392	.004	.004	1	2
UPPER_AERODIGESTIVE_TRACT	CCP110 →	+5.392	+5.392	.004	.004	1	2
UPPER_AERODIGESTIVE_TRACT	PDE1B →	+5.392	+5.392	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 171 associations by consensus.

BMP15 by ARHGEF9 expression — LUNG_SCLC

Explore this box plot interactively →