ARHGEF7

Across TCGA patient cohorts, ARHGEF7 protein abundance is significantly associated with the RNA expression of many other genes, with 16,791 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ARHGEF7-associated genes across cancer lineages are CLN5, TUBGCP3, and ERCC5. Each is linked with ARHGEF7 in more than 7 cancer types. Because this analysis shows association rather than direction, both ARHGEF7-to-partner and partner-to-ARHGEF7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF7 versus CLN5 in LSCC, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF7→partner) and Y-score (partner→ARHGEF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLN5 →	+0.416	+0.238	<.001	<.001	3	8
BRCA	TUBGCP3 →	+0.520	+0.171	<.001	<.001	3	8
BRCA	ERCC5 →	+0.408	+0.239	<.001	<.001	3	8
BRCA	UPF3A →	+0.746	+0.286	<.001	<.001	3	8
BRCA	ALG11 →	+0.379	+0.161	.001	.007	3	8
LSCC	CDC16 →	+0.488	+0.158	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,791 associations by consensus.

ARHGEF7 vs CLN5 — LSCC

Explore this scatter interactively →