ARHGEF7

Across TCGA patient cohorts, ARHGEF7 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF7-associated genes across cancer lineages are eEF2, EGFR_pY1173, and A-Raf_pS299. Each is linked with ARHGEF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF7-to-partner and partner-to-ARHGEF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ARHGEF7-low versus ARHGEF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF7→partner) and Y-score (partner→ARHGEF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.290	+1.874	.003	<.001	3	2
UCEC	EGFR_pY1173 →	+0.069	+1.026	.001	.022	3	2
UCEC	A-Raf_pS299 →	-0.118	-2.415	<.001	.002	3	2
UCEC	GAPDH →	+0.406	+1.847	.006	.007	3	2
UCEC	NF-kB-p65_pS536 →	-0.384	-1.449	.002	.011	3	2
UCEC	Smad3 →	+0.145	+1.157	<.001	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

eEF2 by ARHGEF7 expression — UCEC

Explore this box plot interactively →