ARHGEF7

Across TCGA cell cohorts, ARHGEF7 mutation is significantly associated with the RNA expression of many other genes, with 316 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF7-associated genes across cancer lineages are SLC38A8, FAM24A, and FAM236A. Each is linked with ARHGEF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF7-to-partner and partner-to-ARHGEF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC38A8 grouped by ARHGEF7-low versus ARHGEF7-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF7→partner) and Y-score (partner→ARHGEF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC38A8 →	+0.084	+3.606	<.001	.002	3	2
PANCREAS	FAM24A →	+0.083	+5.614	<.001	.002	3	1
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.120	+5.357	<.001	.003	3	1
STOMACH	IL22 →	+0.046	+5.285	<.001	.003	3	1
STOMACH	SPAG11B →	+0.076	+5.285	<.001	.003	3	1
STOMACH	TEX26 →	+0.049	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 316 associations by consensus.

SLC38A8 by ARHGEF7 expression — BLOOD_Lymphoma

Explore this box plot interactively →