Across TCGA pan-cancer cohorts, ARHGEF7-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ARHGEF7-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where ARHGEF7-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ARHGEF7-AS1 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

BRCA, THCA, and KIRP are the cancer types where ARHGEF7-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGEF7-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	−0.193	<.001	6	view →
THCA	Male	IV	−0.230	<.001	2	view →
KIRP	All	All	−0.125	.002	2	view →
LUSC	All	II,III,IV	−0.055	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ARHGEF7-AS1 RNA expression & survival · all ARHGEF7-AS1 data types