ARHGEF6

Across TCGA patient cohorts, ARHGEF6 protein abundance is significantly associated with the RNA expression of many other genes, with 16,853 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ARHGEF6-associated genes across cancer lineages are LILRB1, RASAL3, and CRTAM. Each is linked with ARHGEF6 in more than 9 cancer types. Because this analysis shows association rather than direction, both ARHGEF6-to-partner and partner-to-ARHGEF6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF6 versus LILRB1 in COAD, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF6→partner) and Y-score (partner→ARHGEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LILRB1 →	+1.089	+0.375	<.001	<.001	3	10
HNSC	RASAL3 →	+1.091	+0.532	<.001	<.001	3	10
COAD	CRTAM →	+1.165	+0.448	<.001	<.001	3	10
HNSC	SELPLG →	+1.031	+0.403	<.001	<.001	3	10
HNSC	FAM78A →	+1.021	+0.582	<.001	<.001	3	10
HNSC	WDFY4 →	+1.194	+0.545	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,853 associations by consensus.

ARHGEF6 vs LILRB1 — COAD

Explore this scatter interactively →