ARHGEF6

Across TCGA patient cohorts, ARHGEF6 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF6-associated genes across cancer lineages are eIF4E, FASN, and FOXO3a_pS318_S321. Each is linked with ARHGEF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF6-to-partner and partner-to-ARHGEF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ARHGEF6-low versus ARHGEF6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF6→partner) and Y-score (partner→ARHGEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.296	+3.182	<.001	.009	3	2
COAD	FASN →	+0.610	+2.467	<.001	.011	3	2
COAD	FOXO3a_pS318_S321 →	-0.151	-2.433	.033	.020	3	2
COAD	PCNA →	+0.319	+2.467	.002	.011	3	2
COAD	SF2 →	+0.143	+2.467	.017	.011	3	2
COAD	Bid →	+0.098	+3.000	.047	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

eIF4E by ARHGEF6 expression — COAD

Explore this box plot interactively →