ARHGEF6

Across TCGA cell cohorts, ARHGEF6 mutation is significantly associated with the drug of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARHGEF6-associated genes across cancer lineages are Pyridostatin, Mirin, and Capivasertib. Each is linked with ARHGEF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF6-to-partner and partner-to-ARHGEF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pyridostatin grouped by ARHGEF6-low versus ARHGEF6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF6→partner) and Y-score (partner→ARHGEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Pyridostatin →	+0.685	+3.035	<.001	.014	3	2
BLOOD_Leukemia	Mirin →	+0.330	+2.922	.006	.021	3	1
BLOOD_Leukemia	Capivasertib →	+0.860	+2.658	.001	.043	3	1
BLOOD_Leukemia	AZ20 →	+0.385	+3.037	.036	.014	3	1
BLOOD_Leukemia	UNC0642 →	+0.151	+3.228	.042	.009	2	2
BLOOD_Leukemia	Dactinomycin →	+0.431	+2.700	.021	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Pyridostatin by ARHGEF6 expression — BLOOD_Leukemia

Explore this box plot interactively →