ARHGEF5

Across TCGA pan-cancer cohorts, ARHGEF5 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ARHGEF5 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ARHGEF5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ARHGEF5 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

COAD, UCEC, and PDAC are the cancer types where ARHGEF5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.920	.025	48	view →
UCEC	DFS	Tertile	II,III,IV	1.000	0.408	.002	26	view →
PDAC	OS	Quartile	III,IV	1.000	0.298	.006	20	view →
LUAD	DFS	Median	II,III,IV	0.238	0.814	.016	12	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.773	.006	8	view →
CCRCC	OS	Median	All	0.751	1.000	.038	6	view →
HNSC	DFS	Median	II,III,IV	0.750	0.570	.034	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ARHGEF5–COAD (DFS)

Open the COAD breakdown →