ARHGEF5

Across TCGA patient cohorts, ARHGEF5 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,908 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ARHGEF5-associated proteins across cancer lineages are UBE3C, SSBP1, and CUL1. Each is linked with ARHGEF5 in more than 5 cancer types. Because this analysis shows association rather than direction, both ARHGEF5-to-partner and partner-to-ARHGEF5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF5 versus UBE3C in HNSC, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF5→partner) and Y-score (partner→ARHGEF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UBE3C →	+0.293	+0.741	<.001	<.001	3	5
LSCC	SSBP1 →	+0.450	+0.883	<.001	<.001	3	5
HNSC	CUL1 →	+0.274	+0.852	<.001	<.001	3	5
LSCC	ARHGEF5_S1011 →	+0.830	+0.706	<.001	<.001	3	5
HNSC	ARHGEF5_S606 →	+0.596	+0.900	<.001	<.001	3	5
CCRCC	VPS50 →	+0.157	+0.574	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,908 associations by consensus.

ARHGEF5 vs UBE3C — HNSC

Explore this scatter interactively →