ARHGEF5

Across TCGA patient cohorts, ARHGEF5 protein abundance is significantly associated with the RNA expression of many other genes, with 20,031 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ARHGEF5-associated genes across cancer lineages are ARHGEF34P, ARHGEF35, and CTAGE4. Each is linked with ARHGEF5 in more than 7 cancer types. Because this analysis shows association rather than direction, both ARHGEF5-to-partner and partner-to-ARHGEF5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF5 versus ARHGEF34P in GBM, with a Pearson correlation of 0.87.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF5→partner) and Y-score (partner→ARHGEF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGEF34P →	+1.515	+2.467	.003	.004	3	8
LSCC	ARHGEF35 →	+0.916	+0.415	<.001	<.001	3	7
HNSC	CTAGE4 →	+0.603	+0.348	<.001	<.001	3	7
LSCC	CTAGE8 →	+0.361	+0.331	.001	.002	3	6
HNSC	MKRN1 →	+0.474	+0.302	<.001	<.001	3	6
OV	RSBN1L →	+0.458	+0.350	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,031 associations by consensus.

ARHGEF5 vs ARHGEF34P — GBM

Explore this scatter interactively →