ARHGEF5

Across TCGA patient cohorts, ARHGEF5 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF5-associated genes across cancer lineages are ERK2, 14-3-3_beta, and MEK1. Each is linked with ARHGEF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF5-to-partner and partner-to-ARHGEF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ARHGEF5-low versus ARHGEF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF5→partner) and Y-score (partner→ARHGEF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.171	+1.906	.027	.016	3	2
UCEC	14-3-3_beta →	-0.111	-3.432	.006	.005	3	1
UCEC	MEK1 →	+0.375	+2.459	.010	.019	3	1
UCEC	p27_pT198 →	+0.091	+1.906	.034	.016	3	1
UCEC	p70-S6K_pT389 →	-0.160	-3.169	.036	.018	3	1
UCEC	P-Cadherin →	-0.131	-3.169	.023	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ERK2 by ARHGEF5 expression — UCEC

Explore this box plot interactively →