ARHGEF5

Across TCGA cell cohorts, ARHGEF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,553 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible ARHGEF5-associated GO terms across cancer lineages are Cilium movement, Endosomal transport, and Vacuolar transport. Each is linked with ARHGEF5 in more than 11 cancer types. Because this analysis shows association rather than direction, both ARHGEF5-to-partner and partner-to-ARHGEF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cilium movement grouped by ARHGEF5-low versus ARHGEF5-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF5→partner) and Y-score (partner→ARHGEF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cilium movement →	-0.101	-0.891	<.001	.001	3	12
OVARY	Endosomal transport →	+0.046	+1.342	<.001	.002	3	12
OVARY	Vacuolar transport →	+0.050	+1.732	<.001	<.001	3	11
OVARY	Lysosomal transport →	+0.052	+1.442	<.001	<.001	3	11
LUNG_NSCLC_LUAD	Extracellular vesicle biogenesis →	+0.105	+1.428	.003	.001	3	10
STOMACH	Regulation of Rho protein signal transduction →	+0.114	+2.265	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,553 associations by consensus.

Cilium movement by ARHGEF5 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →