ARHGEF5

Across TCGA cell cohorts, ARHGEF5 mutation is significantly associated with the RNA expression of many other genes, with 996 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF5-associated genes across cancer lineages are RETNLB, PYURF, and PBOV1. Each is linked with ARHGEF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF5-to-partner and partner-to-ARHGEF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RETNLB grouped by ARHGEF5-low versus ARHGEF5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF5→partner) and Y-score (partner→ARHGEF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RETNLB →	+0.342	+5.321	<.001	.005	3	2
LARGE_INTESTINE	PYURF →	+0.478	+3.321	<.001	.002	3	2
OVARY	PBOV1 →	+0.067	+3.855	<.001	.001	3	2
LARGE_INTESTINE	C18orf25 →	+0.582	+3.523	.004	.001	3	2
LARGE_INTESTINE	POMK →	+0.915	+2.584	.002	.002	3	2
LARGE_INTESTINE	C4orf47 →	+0.318	+2.541	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 996 associations by consensus.

RETNLB by ARHGEF5 expression — CNS

Explore this box plot interactively →