ARHGEF39

Across TCGA patient cohorts, ARHGEF39 mutation is significantly associated with the immune_cell of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF39-associated genes across cancer lineages are Macrophages, CD8+ naive T-cells, and Mesangial cells. Each is linked with ARHGEF39 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF39-to-partner and partner-to-ARHGEF39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macrophages grouped by ARHGEF39-low versus ARHGEF39-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF39→partner) and Y-score (partner→ARHGEF39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Macrophages →	+0.041	+3.288	<.001	.041	3	1
UCEC	CD8+ naive T-cells →	+0.025	+2.839	.046	.034	3	1
UCEC	Mesangial cells →	-0.047	-2.574	.009	.011	3	1
UCEC	Myocytes →	+0.046	+3.601	.002	.001	3	1
UCEC	Osteoblast →	-0.052	-3.281	.013	.010	3	1
UCEC	pDC →	+0.078	+2.595	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Macrophages by ARHGEF39 expression — COAD

Explore this box plot interactively →