ARHGEF38

Across TCGA patient cohorts, ARHGEF38 mutation is significantly associated with the RNA expression of many other genes, with 2,942 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF38-associated genes across cancer lineages are RPL23AP45, RN7SL335P, and RPS16P3. Each is linked with ARHGEF38 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF38-to-partner and partner-to-ARHGEF38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP45 grouped by ARHGEF38-low versus ARHGEF38-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF38→partner) and Y-score (partner→ARHGEF38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL23AP45 →	+0.098	+5.097	<.001	.008	3	3
LUSC	RN7SL335P →	+0.064	+4.780	.003	.003	3	3
COAD	RPS16P3 →	+0.247	+5.893	<.001	.002	3	2
STAD	RBMY2AP →	+0.032	+7.091	<.001	<.001	3	2
LUSC	RNU6-704P →	+0.692	+3.829	<.001	.001	3	2
READ	TRDJ3 →	+0.722	+4.445	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,942 associations by consensus.

RPL23AP45 by ARHGEF38 expression — SKCM

Explore this box plot interactively →