ARHGEF38

Across TCGA patient cohorts, ARHGEF38 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF38-associated genes across cancer lineages are Ku80, S6_pS240_S244, and ATM. Each is linked with ARHGEF38 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF38-to-partner and partner-to-ARHGEF38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ARHGEF38-low versus ARHGEF38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF38→partner) and Y-score (partner→ARHGEF38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.230	+2.125	.009	.010	3	2
UCEC	S6_pS240_S244 →	+0.332	+1.765	.029	.014	3	2
UCEC	ATM →	-0.545	-2.308	.001	.033	3	2
UCEC	EGFR_pY1068 →	-0.205	-1.765	.029	.014	3	1
UCEC	eIF4G →	+0.253	+2.999	.029	.035	3	1
UCEC	A-Raf_pS299 →	-0.103	-2.700	.021	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Ku80 by ARHGEF38 expression — UCEC

Explore this box plot interactively →