ARHGEF38

Across TCGA cell cohorts, ARHGEF38 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF38-associated genes across cancer lineages are SLC32A1, CLLU1-AS1, and CFAP97D2. Each is linked with ARHGEF38 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF38-to-partner and partner-to-ARHGEF38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by ARHGEF38-low versus ARHGEF38-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF38→partner) and Y-score (partner→ARHGEF38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SLC32A1 →	+0.016	+5.087	<.001	.004	3	1
URINARY_TRACT	CLLU1-AS1 →	+0.113	+5.087	<.001	.004	3	1
URINARY_TRACT	CFAP97D2 →	+0.043	+5.087	<.001	.004	3	1
LARGE_INTESTINE	C1QTNF7 →	+0.074	+4.108	.003	.008	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	WDR87 →	+0.021	+3.453	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SLC32A1 by ARHGEF38 expression — URINARY_TRACT

Explore this box plot interactively →