Across TCGA patient cohorts, ARHGEF37 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF37-associated genes across cancer lineages are ATM, PDK1_pS241, and Stathmin. Each is linked with ARHGEF37 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF37-to-partner and partner-to-ARHGEF37 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF37→partner) and Y-score (partner→ARHGEF37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.461	-4.169	.011	<.001	3	2
SKCM	PDK1_pS241 →	-0.274	-3.304	.001	.010	3	1
SKCM	Stathmin →	+0.194	+3.025	.036	.018	3	1
SKCM	Bax →	-0.236	-3.321	.048	.010	3	1
SKCM	Cyclin-B1 →	+0.583	+2.820	.005	.035	3	1
UCEC	EGFR_pY1068 →	-0.231	-2.415	.022	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

ARHGEF37 survival (RNA) · tumor vs normal (RNA) · all ARHGEF37 data types