Across TCGA pan-cancer cohorts, ARHGEF35 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ARHGEF35 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ARHGEF35 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ARHGEF35 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and CCRCC are the cancer types where ARHGEF35 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.979	0.832	.005	32	view →
HNSC	OS	Tertile	III,IV	0.845	0.565	.013	28	view →
CCRCC	DFS	Quartile	II,III,IV	0.260	0.820	.006	16	view →
LUAD	OS	Median	II,III,IV	1.000	0.807	.010	10	view →
LSCC	DFS	Median	III,IV	0.644	0.930	.041	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ARHGEF35 tumor-vs-normal RNA expression · all ARHGEF35 data types