Across TCGA patient cohorts, ARHGEF35 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,547 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ARHGEF35-associated proteins across cancer lineages are ARHGEF5, ARHGEF35_S450, and ARHGEF5_S606. Each is linked with ARHGEF35 in more than 6 cancer types. Because this analysis shows association rather than direction, both ARHGEF35-to-partner and partner-to-ARHGEF35 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF35→partner) and Y-score (partner→ARHGEF35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGEF5 →	+0.424	+0.830	<.001	<.001	3	7
UCEC	ARHGEF35_S450 →	+0.927	+0.685	<.001	<.001	3	6
BRCA	ARHGEF5_S606 →	+0.626	+0.904	<.001	<.001	3	5
LSCC	ARHGEF5_S1004 →	+1.259	+1.280	<.001	<.001	3	4
BRCA	SPEN_S1622 →	-0.744	-0.767	.005	.004	3	3
OV	TAGLN3 →	-1.315	-0.963	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,547 associations by consensus.

Exploration

ARHGEF35 survival (RNA) · tumor vs normal (RNA) · all ARHGEF35 data types