Across TCGA patient cohorts, ARHGEF33 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF33-associated genes across cancer lineages are ATM, 14-3-3_beta, and eEF2. Each is linked with ARHGEF33 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF33-to-partner and partner-to-ARHGEF33 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF33→partner) and Y-score (partner→ARHGEF33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.425	-2.584	.012	.010	3	2
UCEC	14-3-3_beta →	-0.127	-3.673	<.001	.001	3	1
UCEC	eEF2 →	+0.411	+3.459	.002	.005	3	1
UCEC	EGFR_pY1068 →	-0.293	-2.584	.001	.010	3	1
UCEC	eIF4E →	+0.169	+2.584	.032	.010	2	2
UCEC	A-Raf_pS299 →	-0.157	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

ARHGEF33 survival (RNA) · tumor vs normal (RNA) · all ARHGEF33 data types