ARHGEF3

Across TCGA patient cohorts, ARHGEF3 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF3-associated genes across cancer lineages are MEK1, p62 Lck ligand, and Snail. Each is linked with ARHGEF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF3-to-partner and partner-to-ARHGEF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ARHGEF3-low versus ARHGEF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF3→partner) and Y-score (partner→ARHGEF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.291	+1.847	.030	.008	3	2
UCEC	p62 Lck ligand →	+0.293	+2.736	.014	<.001	3	2
UCEC	Snail →	-0.247	-3.906	.035	<.001	3	2
UCEC	C-Raf →	+0.164	+1.847	.001	.008	3	2
UCEC	14-3-3_beta →	-0.093	-3.295	.011	.009	3	1
UCEC	EGFR_pY1068 →	-0.198	-2.247	.032	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MEK1 by ARHGEF3 expression — UCEC

Explore this box plot interactively →