ARHGEF3

Across TCGA cell cohorts, ARHGEF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,980 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ARHGEF3-associated GO terms across cancer lineages are Positive regulation of small GTPase mediated signal transduction, Positive regulation of T cell differentiation, and Positive regulation of lymphocyte differentiation. Each is linked with ARHGEF3 in more than 9 cancer types. Because this analysis shows association rather than direction, both ARHGEF3-to-partner and partner-to-ARHGEF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of small GTPase mediated signal transduction grouped by ARHGEF3-low versus ARHGEF3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF3→partner) and Y-score (partner→ARHGEF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of small GTPase mediated signal transduction →	+0.079	+0.856	.004	.005	2	10
KIDNEY	Positive regulation of T cell differentiation →	+0.086	+1.269	.004	.001	2	10
LUNG_NSCLC_LUSC	Positive regulation of lymphocyte differentiation →	+0.093	+0.831	.001	.007	2	10
LUNG_NSCLC_LUAD	Positive regulation of leukocyte cell-cell adhesion →	+0.060	+0.840	<.001	<.001	3	8
PANCREAS	Rho protein signal transduction →	+0.123	+1.295	.001	<.001	3	8
PANCREAS	Positive regulation of Rho protein signal transduction →	+0.148	+1.078	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,980 associations by consensus.

Positive regulation of small GTPase mediated signal transduction by ARHGEF3 expression — PANCREAS

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