ARHGEF3

Across TCGA cell cohorts, ARHGEF3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF3-associated genes across cancer lineages are SPIC, NUPR2, and BTNL2. Each is linked with ARHGEF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF3-to-partner and partner-to-ARHGEF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPIC grouped by ARHGEF3-low versus ARHGEF3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF3→partner) and Y-score (partner→ARHGEF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPIC →	+0.304	+4.095	<.001	.009	3	1
LARGE_INTESTINE	NUPR2 →	+0.376	+4.273	<.001	.006	3	1
LARGE_INTESTINE	BTNL2 →	+0.081	+4.415	<.001	.007	3	1
LARGE_INTESTINE	F11 →	+0.057	+4.467	<.001	.004	3	1
BLOOD_Leukemia	KCNK4 →	+0.215	+4.145	<.001	<.001	3	1
BLOOD_Leukemia	TEX48 →	+0.034	+3.890	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SPIC by ARHGEF3 expression — LARGE_INTESTINE

Explore this box plot interactively →