ARHGEF26

Across TCGA patient cohorts, ARHGEF26 mutation is significantly associated with the RNA expression of many other genes, with 4,985 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF26-associated genes across cancer lineages are PAPLN, TXNL4A, and WDR41. Each is linked with ARHGEF26 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF26-to-partner and partner-to-ARHGEF26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAPLN grouped by ARHGEF26-low versus ARHGEF26-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF26→partner) and Y-score (partner→ARHGEF26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PAPLN →	-0.676	-2.489	<.001	.002	3	3
COAD	TXNL4A →	+0.531	+3.169	<.001	<.001	3	3
COAD	WDR41 →	+0.503	+3.210	<.001	<.001	3	3
UCEC	PSMB2 →	+0.233	+1.491	.009	<.001	3	3
COAD	UBE2F →	+0.343	+2.515	<.001	.001	3	3
UCEC	HSBP1L1 →	+0.462	+1.628	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,985 associations by consensus.

PAPLN by ARHGEF26 expression — COAD

Explore this box plot interactively →