ARHGEF26

Across TCGA patient cohorts, ARHGEF26 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ARHGEF26-associated genes across cancer lineages are eIF4E, HER2_pY1248, and MEK1. Each is linked with ARHGEF26 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF26-to-partner and partner-to-ARHGEF26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ARHGEF26-low versus ARHGEF26-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF26→partner) and Y-score (partner→ARHGEF26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.218	+3.597	.001	.001	3	2
UCEC	HER2_pY1248 →	-0.167	-1.688	.032	.001	3	2
UCEC	MEK1 →	+0.398	+2.137	<.001	<.001	3	2
COAD	PCNA →	+0.303	+2.330	<.001	.003	3	2
COAD	Rad50 →	-0.376	-3.584	<.001	.002	3	2
UCEC	Annexin-1 →	+0.509	+1.827	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

eIF4E by ARHGEF26 expression — COAD

Explore this box plot interactively →