ARHGEF26

Across TCGA cell cohorts, ARHGEF26 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,640 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ARHGEF26-associated GO terms across cancer lineages are Cell cycle checkpoint signaling, Negative regulation of cell cycle process, and Spindle assembly. Each is linked with ARHGEF26 in more than 13 cancer types. Because this analysis shows association rather than direction, both ARHGEF26-to-partner and partner-to-ARHGEF26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle checkpoint signaling grouped by ARHGEF26-low versus ARHGEF26-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF26→partner) and Y-score (partner→ARHGEF26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Cell cycle checkpoint signaling →	+0.066	+1.247	.001	.003	2	14
OVARY	Negative regulation of cell cycle process →	+0.053	+1.245	<.001	<.001	3	13
LUNG_SCLC	Spindle assembly →	+0.063	+1.417	.002	<.001	3	12
LIVER	Regulation of DNA repair →	+0.076	+1.693	.004	.001	3	12
LIVER	Positive regulation of cation transmembrane transport →	-0.125	-1.423	.002	<.001	3	12
LIVER	Mitotic cell cycle checkpoint signaling →	+0.078	+1.329	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,640 associations by consensus.

Cell cycle checkpoint signaling by ARHGEF26 expression — LIVER

Explore this box plot interactively →