ARHGEF26

Across TCGA cell cohorts, ARHGEF26 mutation is significantly associated with the RNA expression of many other genes, with 487 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF26-associated genes across cancer lineages are NXF5, SLC30A7, and TDRD5. Each is linked with ARHGEF26 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF26-to-partner and partner-to-ARHGEF26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXF5 grouped by ARHGEF26-low versus ARHGEF26-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF26→partner) and Y-score (partner→ARHGEF26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NXF5 →	+0.032	+4.087	<.001	.004	3	3
LARGE_INTESTINE	SLC30A7 →	+0.515	+2.936	<.001	<.001	3	2
LARGE_INTESTINE	TDRD5 →	+0.600	+2.541	<.001	.004	3	2
BLOOD_Myeloma	OR2T35 →	+0.086	+4.807	<.001	.006	3	1
BLOOD_Myeloma	MUC5AC →	+0.018	+4.807	<.001	.006	3	1
LIVER	CLDN17 →	+0.021	+3.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 487 associations by consensus.

NXF5 by ARHGEF26 expression — CNS

Explore this box plot interactively →